The effect of different water and nitrogen applications on some yield parameters and antioxidant activity on sage (Salvia officinalis L. var. Extrakta) was investigated. A field trial was arranged in the split plot design with four replications under the Bornova ecological conditions in 2012 and 2013. The following water regimes were used as main plots: S1 (irrigated when it’s needed), S2 (20 days dry before harvesting) and S3 (40 days dry before harvesting) and nitrogen applications were used as sub-plots such as 0 kg ha-1 and 60 kg ha -1 . The following plant characteristics such as plant height (cm), fresh herbage yield (kg ha −1 ), drug herbage yield (kg ha −1 ), drug leaf yield (kg ha −1 ), essential oil ratio (%), essential oil yield, essential oil content (%), antioxidant capacity (μmol FRAPgDM) were recorded. The highest essential oil ratio was obtained from the S3 water dose such as 2.07%. The main component in the essential oils recovered by both experiments were α+β thujone showing a large variation. Considering the N fertilization combined with the S2 irrigation had positive effect on the characteristics measured. It could be concluded that the antioxidant activity tended to increase as the soil moisture decreased.