This study was conducted to investigate seed yield stability of the safflower (Carthamus tinctorius L.) genotypes grown for five years (2014-2018) under different climate conditions of Central Anatolia Region with large differences in climate conditions year to year in Turkey. A total of 17 safflower genotypes were used in this study. Experiments were conducted in randomized blocks design with four replications. The parameters of S⁽¹⁾, S⁽²⁾, S⁽³⁾, S⁽⁶⁾, NP⁽¹⁾, NP⁽²⁾, NP⁽³⁾, NP⁽⁴⁾, Wᵢ², σ²ᵢ, s²dᵢ, bᵢ, CVi, θ₍ᵢ₎ and θᵢ, ????R were used to determine seed yield stability of the genotypes. Biplot graphs were used for visual assessment of the relationships among the methods utilized. Gokturk, Dincer 5-118, G5 and G9 genotypes were identified as stable based on majority of the methods and they had seed yields greater than the general averages (2.90, 2.85, 2.83 and 2.82 t ha-1 , respectively). Based on the relationships among the methods, present parameters were divided into four groups. Present findings revealed that Group I (S⁽⁶⁾, NP⁽²⁾, NP⁽³⁾, NP⁽⁴⁾, ????R) could be used as selection criteria to determine high-yield and stable genotypes. Instead of using several methods to identify stable genotypes, a single parameter from each group of methods will be sufficient. The stable and high-yield genotype G9 was registered in 2019 in Turkey under the name of “Koc”.