CHANGES OF SERUM MIR-202-3P LEVEL AND ITS CORRELATION WITH PROGNOSIS IN PATIENTS WITH ACUTE KIDNEY INJURY INDUCED BY SEPSIS

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Yueyao Chen, Shiqun Zhou, Haixiang Li

Abstract

Objective: To investigate the changes of serum miR-202-3p level and its correlation with prognosis in patients with acute kidney injury (AKI) induced by sepsis. Methods: From April 2017 to January 2019, 66 patients with AKI induced by sepsis in our hospital and 70 healthy people in the same period were selected as the research objects. The levels of miR-202-3p, BUN and Cr in serum were tested. Subsequently, cell experiments were carried out to verify the effects of the decrease of miR-202-3p level on BUN, Cr and cell growth and apoptosis. The risk factors were analysed. Results: Compared with healthy volunteers, patients with AKI induced by sepsis had higher levels of miR-202-3p, BUN and Cr in serum. When miR-202-3p level was knocked down, the levels of BUN and Cr were declined, cell growth was improved and apoptosis rate was decreased. The risk factors were analysed, and the results revealed that miR-202-3p, BUN and Cr were independent risk factors for poor prognosis in patients with AKI induced by sepsis. Conclusion: The level of miR-202-3p is elevated in patients with AKI induced by sepsis, which may be a potential biomarker for diagnosis and prognosis of patients with AKI induced by sepsis.

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