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Objective: The paper aimed to investigate the role of miR-144-5p in the invasion of lung cancer cells (A549) through AKT/p-catenin signaling pathway and the inherent mechanism. Methods: After miR-144-5p was transfected into lung cancer cells, MTT and flow cytometry were used to detect apoptosis, Transwell was employed to detect cell invasion, and immunofluorescence staining and Western blotting were applied to determine the expression of various proteins.Results: MTT and flow cytometry results showed that miR-144-5p can reduce the proliferation of A549 cells and promote apoptosis. Transwell experiments confirmed that miR-144-5p can significantly reduce the invasion of A549 cells. Immunofluorescence staining and western blotting results exhibited that miR-144-5p can down-regulate the expressions of p-AKT (Ser473) and p-AKT (Thr308) in AKT signals, as well as p-P-catenin (Ser552) in p-catenin signals, thereby inhibiting signal transmission in the AKT/p-catenin signaling pathway.